Per-Ove Sjöquist Selected Research

H290-51

1/2021	Methamphetamine exacerbates pathophysiology of traumatic brain injury at high altitude. Neuroprotective effects of nanodelivery of a potent antioxidant compound H-290/51.
1/2018	Cold Environment Exacerbates Brain Pathology and Oxidative Stress Following Traumatic Brain Injuries: Potential Therapeutic Effects of Nanowired Antioxidant Compound H-290/51.
10/2015	Nanoparticles Exacerbate Both Ubiquitin and Heat Shock Protein Expressions in Spinal Cord Injury: Neuroprotective Effects of the Proteasome Inhibitor Carfilzomib and the Antioxidant Compound H-290/51.
1/2010	Alterations in blood-brain barrier function and brain pathology by morphine in the rat. Neuroprotective effects of antioxidant H-290/51.
1/2010	A new antioxidant compound H-290/51 attenuates nanoparticle induced neurotoxicity and enhances neurorepair in hyperthermia.
8/2009	Chronic treatment with nanoparticles exacerbate hyperthermia induced blood-brain barrier breakdown, cognitive dysfunction and brain pathology in the rat. Neuroprotective effects of nanowired-antioxidant compound H-290/51.

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Per-Ove Sjöquist Research Topics

Disease

12	Reperfusion Injury 01/2017 - 09/2002
10	Myocardial Ischemia (Ischemic Heart Diseases) 11/2013 - 08/2002
10	Ischemia 10/2013 - 07/2002
9	Infarction (Infarctions) 01/2017 - 09/2002
5	Wounds and Injuries (Trauma) 01/2021 - 08/2009
5	Edema (Dropsy) 01/2021 - 08/2009
4	Brain Edema (Cerebral Edema) 01/2021 - 01/2010
2	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2021 - 01/2018
2	Heart Failure 07/2018 - 11/2004
2	Spinal Cord Injuries (Spinal Cord Injury) 10/2015 - 08/2009
2	Myocardial Infarction 11/2013 - 01/2010
2	Hyperthermia 01/2010 - 08/2009
1	Brain Injuries (Brain Injury) 01/2020
1	Fibrosis (Cirrhosis) 07/2018
1	Thrombosis (Thrombus) 07/2018
1	Cardiomyopathies (Cardiomyopathy) 07/2018
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2017
1	Atherosclerosis 11/2013
1	Heart Diseases (Heart Disease) 01/2010
1	Morphine Dependence 01/2010
1	Substance-Related Disorders (Drug Abuse) 01/2010
1	Cognitive Dysfunction 08/2009
1	Insulin Resistance 03/2009
1	Type 2 Diabetes Mellitus (MODY) 04/2008
1	Cardiovascular Diseases (Cardiovascular Disease) 04/2008
1	Myocardial Reperfusion Injury 10/2002

Drug/Important Bio-Agent (IBA)

7	Nitric Oxide (Nitrogen Monoxide)FDA Link 10/2013 - 10/2002
6	H290-51IBA 01/2021 - 08/2009
6	AntioxidantsIBA 01/2021 - 08/2009
6	ArginaseIBA 01/2017 - 01/2010
5	Pharmaceutical PreparationsIBA 01/2020 - 07/2002
5	Evans Blue (Blue, Evans)FDA Link 01/2018 - 09/2002
4	Nitric Oxide Synthase (NO Synthase)IBA 01/2017 - 04/2008
4	clevidipine FDA Link 01/2004 - 08/2002
3	Neuroprotective AgentsIBA 01/2021 - 08/2009
3	Arginine (L-Arginine)FDA Link 10/2013 - 01/2010
2	AlbuminsIBA 01/2018 - 01/2010
2	omega-N-Methylarginine (NG Monomethyl L Arginine)IBA 01/2017 - 01/2012
2	mitochondrial K(ATP) channelIBA 07/2013 - 02/2005
2	CalciumIBA 10/2002 - 09/2002
1	Glutathione (Reduced Glutathione)IBA 01/2021
1	Oxidants (Oxidizing Agents)IBA 01/2021
1	Peroxidase (Myeloperoxidase)IBA 01/2021
1	Methamphetamine (Desoxyn)FDA LinkGeneric 01/2021
1	MetalsIBA 01/2021
1	Nitric Oxide Synthase Type I (Neuronal Nitric Oxide Synthase)IBA 01/2021
1	Malondialdehyde (Propanedial)IBA 01/2021
1	beta CateninIBA 01/2021
1	Insulin-Like Growth Factor I (IGF-1)IBA 01/2021
1	Proteins (Proteins, Gene)FDA Link 01/2021
1	Insulin (Novolin)FDA Link 01/2021
1	cerebrolysinIBA 01/2020
1	AZD 0837IBA 07/2018
1	AntithrombinsIBA 07/2018
1	Oxytocin Receptors (Oxytocin Receptor)IBA 07/2018
1	Thrombin FDA Link 07/2018
1	Therapeutic UsesIBA 01/2018
1	Streptozocin (Streptozotocin)FDA Link 01/2017
1	N(omega)-hydroxynorarginineIBA 01/2017
1	hydroxyfasudilIBA 01/2017
1	rho-Associated KinasesIBA 01/2017
1	Proteasome InhibitorsIBA 10/2015
1	UbiquitinIBA 10/2015
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 10/2015
1	carfilzomibIBA 10/2015
1	sapropterin (tetrahydrobiopterin)FDA Link 10/2013
1	Protein Kinase C-epsilonIBA 07/2013
1	Adenosine Triphosphate (ATP)IBA 07/2013
1	Hydroxyl RadicalIBA 01/2010
1	IodineIBA 01/2010
1	Morphine (MS Contin)FDA LinkGeneric 01/2010
1	Silicon Dioxide (Silica)FDA LinkGeneric 08/2009
1	Phosphatidylinositol 3-Kinases (PI 3 Kinase)IBA 03/2009
1	LigandsIBA 03/2009
1	Fibric Acids (Fibrates)IBA 03/2009
1	NitratesIBA 03/2009
1	PPAR alphaIBA 03/2009
1	NitritesIBA 03/2009
1	AdiponectinIBA 04/2008
1	AMP-Activated Protein KinasesIBA 04/2008
1	Rosuvastatin Calcium (Crestor)FDA Link 06/2007
1	geranylgeranyl pyrophosphate (geranylgeranyl diphosphate)IBA 06/2007
1	Coenzyme A (CoA)IBA 06/2007
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 06/2007
1	CholesterolIBA 06/2007
1	rhoA GTP-Binding ProteinIBA 06/2007
1	Oxidoreductases (Dehydrogenase)IBA 06/2007
1	Methanol (Carbinol)IBA 06/2007
1	Rosiglitazone (Avandia)FDA Link 01/2007
1	PPAR gammaIBA 01/2007
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2007
1	Endothelin-1 (Endothelin 1)IBA 02/2005
1	Penicillamine (Cuprimine)FDA Link 10/2002
1	Bradykinin B2 ReceptorIBA 10/2002
1	BradykininIBA 10/2002
1	icatibantIBA 10/2002
1	1,4-dihydropyridine (dihydropyridine)IBA 09/2002

Therapy/Procedure

1	Intravenous Infusions 01/2012
1	Induced Hyperthermia (Thermotherapy) 08/2009
1	Intraperitoneal Injections 06/2007